Publications by Year: 2021
Jordan, J. H.; Cheng, H. N.; Easson, M. W.; Yao, W.; Condon, B. D.; Gibb, B. C. Effect of nanocellulose on the properties of cottonseed protein isolate as a paper strength agent. Materials 2021, 14, 4128.
Jordan, J. H.; Ashbaugh, H. S.; Mague, J. T.; Gibb, B. C. Buffer and salt effects in aqueous host—guest systems: Screening, competitive binding, or both?. Journal of the American Chemical Society 2021, 143, 18605-18616.
Yao, W.; Wang, K.; Ismaiel, Y. A.; Wang, R.; Cai, X.; Teeler, M.; Gibb, B. C. Electrostatic Potential Field Effects on Amine Macrocyclizations within Yoctoliter Spaces: Supramolecular Electron Withdrawing/Donating Groups. The Journal of Physical Chemistry B 2021, 125, 9333-9340.
Shusterman-Krush, R.; Tirukoti, N. D.; Bandela, A. K.; Avram, L.; Allouche-Arnon, H.; Cai, X.; Gibb, B. C.; Bar-Shir, A. Single Fluorinated Agent for Multiplexed 19F-MRI with Micromolar Detectability Based on Dynamic Exchange. Angewandte Chemie International Edition 2021, 60, 15405-15411.
Abstract The weak thermal polarization of nuclear spins limits the sensitivity of MRI, even for MR-sensitive nuclei as fluorine-19. Therefore, despite being the source of inspiration for the development of background-free MRI for various applications, including for multiplexed imaging, the inability to map very low concentrations of targets using 19F-MRI raises the need to further enhance this platform s capabilities. Here, we employ the principles of CEST-MRI in 19F-MRI to obtain a 900-fold signal amplification of a biocompatible fluorinated agent, which can be presented in a “multicolor” fashion. Capitalizing on the dynamic interactions in host–guest supramolecular assemblies in an approach termed GEST, we demonstrate that an inhalable fluorinated anesthetic can be used as a single 19F-probe for the concurrent detection of micromolar levels of two targets, with potential in vivo translatability. Further extending GEST with new designs could expand the applicability of 19F-MRI to the mapping of targets that have so-far remained non-detectable.